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BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations

Axios , Insurers push back on GLP-1 coverage (Feb 2025) ( [65] )

In 1992, exendin-4, which can stimulate insulin secretion, was isolated from Heloderma suspectum venom with 53% homology to mammalian GLP-1, and can resist DPP-4 degradation and has low renal clearance rate (Muttenthaler et al., 2021)

However, individual responses vary widely based on baseline health and medication interactions

Brazil nuts are a food, not a poison, and eating them is not dangerous