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1 The second is a decline in egg quality, driven largely by reduced mitochondrial efficiency inside the egg cell and a gradual build-up of oxidative damage

What has been lacking is an integrated and quantitative understanding of the kinetics of APAP metabolism, of how APAP dosage affects NAPQI synthesis and GSH concentrations in the liver, of how NAC stimulates the synthesis of GSH, and of how the dosage and timing of NAC affect detoxification of NAPQI

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