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Absolute contraindications include personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), previous serious hypersensitivity to semaglutide or formulation components, pregnancy (the medication should be discontinued at least 2 months before planned conception), and breastfeeding due to insufficient data on excretion in human milk
9 Richie JP Jr, et al
This review will explore whether complementary mechanisms of action of combined GLP-1 and GIP receptor agonism could be effective and safe new options that are superior to pure GLP-1RAs as therapy for metabolic disorders
Some studies have examined formal cognitive testing, with mixed results
Further targeted research is required to provide more definitive answers and to guide healthcare providers in optimizing treatment for patients with diabetes or obesity who also suffer from GERD
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