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Riduzione del dolore articolare : particolarmente importante per i pazienti con osteoartrite del ginocchio correlata allobesit, con miglioramenti sia nel dolore che nella funzionalit articolare

Eysiaks W, Lilly K, Dilisao F, Toth PP, Bieber LL (1988) The journal of biological chemistry quantitation of the effect of L-Carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria*

Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function

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