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Further, targeted metabolomics results revealed that GGCT knockdown markedly attenuated TCA cycle flux, decreasing key intermediates including pyruvate, succinate and fumarate (Fig

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In the nervous system, the role exerted by GSH and its related enzymes is particularly relevant since neurons are highly sensitive to oxidative stress 50

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10.1016/j.expneurol.2020.113538 Exp Neurol

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