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Most diabetes specialists recommend optimizing a single GLP-1 dose before adding a second incretinotropic agent

If you have a history of pancreatitis, the risk-benefit calculation changes unfavorably unless other factors strongly favor use and careful monitoring is in place

Sin embargo, a pesar de la gran cantidad de evidencia acumulada en los aos siguientes, no se le dio mayor importancia hasta que se conoci que alteraciones en mecanismos renales de regulacin de la glucosa estaban involucradas en la patogenia de la DM2

Triple, quadruple and quintuple agonists are now in development, as is an expanded range of oral formulations

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