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Abbreviations ADRB2/2AR: 2-Adrenergic receptor AKT/PKB: Protein kinase B cAMP: Cyclic adenosine monophosphate CREB: CAMP-response element binding protein DCT: Dopachrome tautomerase EF: Epimedii Folium ERK: Extracellular regulated protein kinases GSK3: Glycogen synthase kinase-3 beta HMVII: Human melanoma cell line HEM: Human epidermal melanocyte MAPK: Mitogen-activated protein kinase McSCs: Melanocyte stem cells MITF: Microphthalmia-associated transcription factor NRF2: Nuclear factor erythroid 2 (E2)-related factor 2 PM: Polygoni multiflori radix PKA: Protein kinase A PTU: 1-Phenyl-2-thiourea TCM: Traditional Chinese medicine TA: Transit-amplifying TPA: 12-O-tetradecanoylphorbol-13-acetate TYR: Tyrosinase TrKA: Tropomyosin receptor kinase A TRP-1: Tyrosinase-related protein 1 TRP-2: Tyrosinase-related protein 2 References Adly MA, et al

A reasonable progression involves adding 10 to 15% to weekly mileage when the previous weeks training produced no significant flare-ups

The most immediately relevant risk relates to glucose metabolism

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