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( d ) Cells were treated with the IDH1 (IDH1i) and olaparib (Olap) or cisplatin (Cis) alone or combined (n = 4 technical replicates representative from independent experiments)
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The clinical presentation can vary widely depending on the type of mutation affecting SLC22A5 and the phenotypic manifestation of the mutation, i.e., age of onset, organ involvement, and severity of symptoms at the time of diagnosis (34)
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