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The target and the pathway in more detail IGF-1 LR3 acts at the type 1 insulin-like growth factor receptor, IGF-1R, and that receptor belongs to a different structural and mechanistic class from the class B G-protein-coupled receptors that dominate the rest of this catalog
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Holz A, Bossinger B, Strasser T, Janning W, Klapper R
It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade
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