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LUPKIN: Marta says making the active ingredients can be done well, but the molecules are complex, and she worries about impurities from maybe something funky happening in the manufacturing process that might cause unexpected long-term side effects

Those using starting doses of semaglutide may find this combination sufficient, while users at higher doses like 1.7 mg may need a more comprehensive approach

doi: 10.1007/s10067-025-07637-z

As with previous dual agonists, the main side effects were gastrointestinal and occurred mostly during the initial dose escalation

If you experience severe reactions, such as difficulty breathing or swelling, seek emergency care immediately