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The work presented here, published in the journal Biomedicine s, builds a bridge between laboratory bench and bedside by showing proof-of-concept that supplementing people with HIV specifically with a combination of glycine and N-acetylcysteine, which we call GlyNAC, as precursors of glutathione, a major antioxidant produced by the body, improves multiple deficits associated with premature aging, said Sekhar
When this control is changed by oxidative or electrophilic signals, Nrf2 can accumulate and increase the expression of antioxidant-response genes, including those involved in GSH synthesis
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These effects can lead to oxidative stress, DNA injury, and apoptosis [79]
