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The SCN receives direct light input from intrinsically photosensitive retinal ganglion cells in the eye, which entrains the clock to the external 24-h light/dark cycle each day

With a slight deficiency, a therapy with oral supplements is completely sufficient

Common gastrointestinal side effects include: Nausea and vomiting : Usually most pronounced during initial treatment and dose escalation, often improving over 48 weeks Diarrhoea or constipation : Can affect hydration and nutritional status Abdominal discomfort : Typically mild and transient Patients can manage mild gastrointestinal symptoms by eating smaller, more frequent meals, avoiding high-fat foods, staying well-hydrated, and taking the medication as directed

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It's important to use the medication regularly and talk to a healthcare provider for long-term success