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This illustrates that reducing circulating levels of IgG may not be enough to bring an added therapeutic benefit to patients in all IgG-driven diseases, which may be because of different underlying pathophysiology across diseases
This can degrade the peptide, altering its structure and function
[12] What little has appeared since is preclinical and mostly concerns engineered analogues rather than DSIP itself for instance, fusion constructs designed to survive in circulation and cross the blood-brain barrier, tested in chemically-induced insomnia models in mice
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