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The weekly doses were administered at 5 mg, 10 mg, 15 mg, 20 mg, or 40 mg for 46 weeks, whereas the biweekly doses were given at 20 mg, 40 mg, and 60 mg for 8 weeks

[20] [7] This conversion is illustrated by the reduction of peroxides (via the sulfenate as an intermediate): GSH + R 2 O 2 GSOR + ROH GSOR + GSH GSSG + ROH Net reaction: 2 GSH + R 2 O 2 GSSG + 2 ROH (R = H, alkyl) and with free radicals, forming glutathionyl radicals (GS ) that may dimerize to disulfide: GSH + R RH + GS 1/2 GSSG Thiyl radicals (such as glutathionyl radicals) are themselves oxidizing species in biology, with a single-electron reduction potential sufficient for oxidation of nucleic acids, proteins and polyunsaturated lipids

In Wilson's disease, copper metabolism is genetically impaired, and any copper supplementation may be contraindicated

Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Abdou TA, Esawy HI, Mohamed GAR, Ahmed HH, Elhabiby MM, Khalil SA, et al