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Taylor, Jessica
The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG
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This means training sessions may feel more sustainable over time, particularly during endurance-focused training blocks or calorie-restricted phases
These factors create oxidative stress, which can deplete your glutathione stores faster than your body can replenish them
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