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Primary carnitine deficiency is a rare metabolic disorder in which an abnormal gene prevents the body from using certain fats for energy, particularly during long periods without food
A metabolism-focused framework can help regulators and investigators by making the therapeutic claim testable: the product should have a defined metabolic target, a reproducible potency assay, a biologically plausible delivery window and biomarkers showing that the target changed in treated patients
That makes it a weaker choice for multi-use storage windows
Phase I: Transformation In the first phase, the liver uses enzymes to begin breaking down fat-soluble toxins into intermediate forms
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