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3.1.2 Anti-inflammatory and immunomodulatory effects Chronic hepatic inflammation, driven by activated Kupffer cells, infiltrating macrophages, and pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF- ) and interleukin-6 (IL-6), is a crucial factor in MASLD progression to steatohepatitis and fibrosis

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doi: 10.1210/clinem/dgab429 60 De BellisADello IacovoABellastellaGSavoiaACozzolinoDSinisiAAet al

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Central nervous system signalling, melanocortin receptor selectivity, and neuroendocrine mechanisms