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Mainly through these mechanisms (27), Pycnogenol supplementation has been shown in RDP human clinical trials to beneficially affect cardiovascular health (9, 11, 12, 2022, 2831), chronic venous insufficiency (32, 33), cognition (13, 14, 3439), joint health (4042), skin health (43, 44), eye health (45, 46), womens health (12, 47, 48), respiratory health and allergies (4951), oral health (52) and sports performance (5356) (Figure 2)
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