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BoNTs are dichain toxins composed of a light chain protease and a heavy chain, which is further divided into two functional domains: an N-terminal translocation domain (H N ) and a C-terminal receptor-binding domain (H C ) 21
Direct head-to-head data against tirzepatide showed CagriSema underperforming the highest tirzepatide dose at 84 weeks meaning monotherapy claims of comparable efficacy are not supported by current Phase 3 evidence
This could include a digital rectal examination, urinalysis, or a prostate-specific antigen test
Just one
Importantly, switching from a reference bDMARD to a biosimilar can lead in subjective increase of disease activity or pain in some patients [177], in contrast to the results from double-blind switch randomized clinical trials [178]
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