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The long plasma half-life of approximately one week allows consistent weekly administration without daily fluctuations
3 However, using Wegovy after gastric bypass is considered off-label, meaning it hasnt been specifically approved for this purpose
This phenomenon had previously been observed with liraglutide analogs, where there was a clear trend for longer fatty acids, with improved affinity for albumin, to be associated with diminished potency for the GLP-1R (53)
The first part is the tip
Week one contributes a small fraction of that
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