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Retatrutide is an investigational triple agonist peptide being developed by Eli Lilly, designed to simultaneously target GLP-1, GIP, and glucagon receptors a mechanism that distinguishes it from currently approved agents such as semaglutide and tirzepatide

This neither supports nor refutes potential benefit

Frequently Asked Questions What happens when you switch from semaglutide to tirzepatide

Neuropsychopharmacology 30:747757 Bolin BL, Alcorn JL III, Reynolds AR et al (2016) Human drug discrimination: A primer and methodological review

Some people switch from semaglutide to tirzepatide because they plateau or cant tolerate higher semaglutide doses