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There is no absolute contraindication, as they work through different mechanisms and are metabolised via distinct pathways, though overlapping side effects require monitoring

Weight-related comorbidities that lower the BMI threshold If your BMI is 27.0-29.9, you qualify for Mounjaro if you have at least one of these conditions: Cardiovascular and metabolic: Hypertension (blood pressure 130/80 mmHg or higher, or on antihypertensive medication) Dyslipidemia (LDL 130 mg/dL or higher, triglycerides 150 mg/dL or higher, or on statin therapy) Type 2 diabetes (this moves you to the diabetes pathway, which has no BMI minimum) Prediabetes (A1C 5.7%-6.4% or fasting glucose 100-125 mg/dL) Coronary artery disease History of stroke or transient ischemic attack Respiratory: Obstructive sleep apnea (diagnosed by sleep study, not just symptoms) Obesity hypoventilation syndrome Musculoskeletal: Osteoarthritis with documented functional impairment Chronic lower back pain attributable to excess weight Metabolic: Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) Polycystic ovary syndrome (PCOS) Reproductive: Infertility related to anovulation and obesity The comorbidity must be documented in your medical record

It acts as a beginning point in the methionine cycle and a precursor of S-adenosylmethionine (SAMe), a vital molecule involved in several biochemical processes

A comprehensive understanding of the TME is of the utmost importance because it provides valuable insights into pathways that could be targeted by novel metabolic therapies for advanced or drug-resistant cancers

Animal experiments All procedures performed in rats were approved by the Institutional Animal Care and Use Committee at the Seattle Childrens Research Institute (IACUC00064) and were in accordance with the National Institutes of Health (NIH) Guide for Care and Use of Laboratory Animals