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The animals were kept under a 12-hour light/dark cycle at a temperature of 25C

From a mechanistic perspective, recognizing a metabolic subtype is clinically informative because it frames reproductive dysfunction as potentially downstream of systemic metabolic stress acting on the hypothalamicpituitaryovarian (HPO) axis, thereby prioritizing metabolic risk reduction as a plausible lever for improving reproductive function and for tailoring treatment intensity

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