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Under the if-all-adhere estimand, participants on CagriSema achieved approximately 15.7% weight reduction at week 68, compared with approximately 3% for placebo
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American Academy of Pediatrics Committee on Fetus and Newborn
Human obesity studies were also conducted during pharmaceutical development, but the largest reported placebo-controlled study did not demonstrate a statistically significant weight-loss benefit, and development for obesity was discontinued
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