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Oral antidiabetic agents may include the following: Educate the patient about the complementary nature of oral antidiabetic agents with other treatment modalities, such as medical nutrition therapy (MNT) and exercise

Subgroup analyses were available for PIONEER 3 and 4, which generally showed consistent treatment effects by background therapy for A1C or body weight (metformin with or without SU in PIONEER 3, metformin with or without SGLT2 inhibitor in PIONEER 4)

On the cardiovascular side, the SUSTAIN-6 trial in 2016 was one of the first to report a significant reduction in major adverse cardiovascular events with semaglutide in adults with type 2 diabetes and high cardiovascular risk (Marso et al., NEJM, 2016)

Additional Resources Press Releases Helix Launches World's Largest Clinico-Genomic Cohort of GLP-1 Agonist Treated Patients Read More Research White Paper: Semaglutide and Weight Management Read More Webinars Metabolic risk factors and BMI-associated variants influencing weight loss with Semaglutide Read More Connect with us!