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The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which evaluated once-weekly semaglutide 2.4 mg for weight management, demonstrated significant weight loss (approximately 15% in STEP 1) that could indirectly affect hormone levels, though testosterone was not systematically reported in these publications

Clinical evidence shows that consistent weekly administration with proper technique maximizes weight loss results while minimizing injection-site discomfort

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Medication Interactions If youre taking blood pressure medications alongside semaglutide, the combination of reduced food and fluid intake with the medications mild blood pressure lowering effects can push blood pressure lower than intended