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(2,3) Mycotoxins have also been shown to impair glutathione recycling, disrupt NRF2-mediated antioxidant signaling, and increase oxidative stress burden, further compromising mitochondrial efficiency and redox balance
Presented for research literature review only Berwert L et al
Because TG2 activity is highly associated with cellular redox status and alterations in the bidirectional flux of cellular thiol modulate TG2 activity, regulation of thiol flux in cells probably affects the TG2-mediated aggregation of the GST tag and its interaction with cellular proteins
C3G not only attenuates cellular and tissue oxidative stress but also reduces Fe 2+ levels, inhibits nuclear receptor coactivator 4 (NCOA4) expression, and concurrently regulates transferrin receptor protein 1 (TfR1) downregulation and ferritin heavy chain 1 (FTH1) upregulation
