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Considering that very little is known about the local and temporal concentrations of NADPH and TGR and the multiple redox-associated conformational states, it is difficult to assess how accurately the biochemical assay with recombinant TGR models the inhibition of TGR in worms ex vivo or in vivo

The tradeoff is that GHK-Cu also won't halt DHT-driven miniaturization the way a 5-alpha reductase inhibitor does

Charles Pyke, et al

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