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if a drug moves efficiently through the regulatory process and has 15 years of term remaining at launch, it is ineligible for any PTE
These effects are attributed not only to the potent antioxidant and hypoglycemic properties of ZnO NPs, but also to their ability to downregulate pro-apoptotic gene expression and upregulate the expression of steroidogenesis-related regulatory genes within testicular tissue (92, 93)
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