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The same compound delivered topically through a serum, applied with microneedling, injected directly into the scalp, or injected subcutaneously into the abdomen will produce very different biological effects

Neither has been studied in injectable formulations

The combination according to the invention, in any form, may be suitable for administration to human subjects, the preferred administration route being oral administration

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However, many studies were conducted in populations with mild to moderate symptoms and lacked active antidepressant comparators, limiting conclusions regarding relative efficacy