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Not all compounded tirzepatide is created equal
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Under current FDA guidance, a 503A pharmacy can compound a GLP-1 medication for a specific patient only when the prescriber documents a "significant difference" - a genuine clinical reason why the compounded formulation serves that patient's specific medical need in a way the commercially available FDA-approved product cannot
Reduce dose and ensure adequate hydration
Blundell, J., et al
This, however, does not apply to other GLP-1RAs approved for the treatment of T2DM, including the same liraglutide (Victoza) and semaglutide (Ozempic or Rybelsus) at lower dosages, prompting several stakeholders to request an updated guidance 232 and more caution in media enthusiasm 233
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