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PMID: 36044324 Morton RW, et al
GIP has further effects beyond insulin secretion by stimulating lipogenesis in adipose tissue and reducing lipolysis [24]
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For example, estrogen signaling has been shown to enhance the anorexigenic effects of GLP-1 RAs by modulating central pathways involved in food reward, which could account for the more pronounced weight loss observed in premenopausal women [49, 50]
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