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PMID: 22537212 | DOI: 10.1111/j.1753-4887.2012.00476.x [21] Machowetz A, Poulsen HE, Gruendel S, et al
FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)
pCPA tiered pricing framework Pricing for publicly funded drug plans is governed by the pan-Canadian Pharmaceutical Alliance tiered framework, based on how many generic manufacturers are in the Canadian market: One generic (single source): Enters at 85% of the brand reference price, or 75% if a pricing agreement with provincial plans exists
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