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What happens next is anyone's guess, says Brunner

These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation [50]

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When combined with stable isotope labeling, this approach allows the tracing of fatty acid substrates (e.g., DHA and EPA) through their conversion pathways and product lineages in disease models, facilitating the construction of individualized lipid mediatorPRLM network maps [315]