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Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
Not only that but you end up with increased amounts of oxidants which have been linked to accelerate the ageing process
This pattern is reported across forums and is consistent with IGF-1's known effects on intracellular hydration and protein synthesis through PI3K/Akt/mTOR (Yoshida & Delafontaine, 2020)
10.1016/j.vph.2017.05.005 93 IsmyJ.SyukriM.EmrilD
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