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Causes of the condition are not fully defined, but at least part of the problem can be contributed to an infection in honey bee guts by the fungus Nosema ceranae

Glucagon suppression: Amylin inhibits glucagon secretion Reduces hepatic glucose production Better glucose control Indirect weight loss benefit Particularly helpful for diabetes 5

When the body is deficient in B12, energy levels can be compromised, leading to symptoms such as extreme fatigue and weakness

bioRxiv2025 Sep 25

Vitamin B12 (cobalamin) is vital for: Nerve function Red blood cell formation Energy production Supporting a healthy pregnancy Deficiency can occur due to poor absorption, certain medications, or restrictive diets (such as vegan or vegetarian)