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These associations persisted after adjustment for age, sex, body mass index, glycemic control, comorbidities, and screening intensity, suggesting that the observed effect extends beyond weight loss alone
moreover, the heightened proliferation and turnover of leukocytes amplify its depletion, since these cells can concentrate vitamin C up to a hundredfold higher than plasma levels, ultimately leading to a substantial reduction in systemic vitamin C availability during sepsis (Oudemans-van Straaten et al., 2014
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Thyroid C-cell tumor s The underlying mechanism for this adverse effect isnt clearly understood
Adverse effects: Most common adverse reactions (incidence 5%) are nausea, abdominal pain, diarrhea, decreased appetite, vomiting and constipation
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