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The combination of all of these symptoms can also cause people with depression to experience persistent fatigue, tiredness, and weakness

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Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)

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10.1007/s10517-018-4074-1 Bull