Comprehensive Medical Screening: Clinicians should evaluate for: Thyroid nodules or goiter : Baseline neck examination and review of recent thyroid ultrasound if clinically indicated Personal or family history of thyroid cancer : Particularly medullary thyroid carcinoma Comorbid conditions : Type 2 diabetes, cardiovascular disease, pancreatitis history Gastrointestinal disorders : Severe gastroparesis (potential contraindication) Renal function : Use caution in patients at risk for volume depletion/renal impairment Psychiatric conditions : Depression, eating disorders Pregnancy status : These medications are not recommended during pregnancy and should be discontinued when pregnancy is recognized Laboratory Assessment: Baseline testing should include: TSH and free T4 Comprehensive metabolic panel (renal and hepatic function) Lipid panel Hemoglobin A1c (if diabetic or prediabetic) Routine calcitonin screening or thyroid ultrasound is not recommended solely for GLP-1 therapy initiation

24+ Months: Long-Term Maintenance Decision At this point, patients and their physician make a shared decision: attempt a carefully managed tapering and transition to maintenance, or continue long-term medication for ongoing metabolic management
This has baffled scientists and frustrated patients, but a new studybased on genetic data collected by 23andMe suggests that common quirks in our genetic code can at least partly explain why it happens
They approve doses that work well and have a safety level they are comfortable with
and The patient is not concurrently being treated with a PBS-subsidised SGLT2 inhibitor, dipeptidyl peptidase-4 (DPP4) inhibitor or another GLP-1 RA for their T2DM For subsequent semaglutide PBS prescriptions, the patient must not be concurrently treated for T2DM with a PBS-subsidised SGLT2 inhibitor, DPP4 inhibitor or another GLP-1 RA