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A separate phase 2a trial studied retatrutide specifically in metabolic dysfunction-associated steatotic liver disease (MASLD, the condition formerly framed as non-alcoholic fatty liver disease)
Li R, Sun X, Li P, Li W, Zhao L, Zhu L, et al
Nardone OM, de Sire R, Petito V, Testa A, Villani G, Scaldaferri F, et al
Consequently, mutations in TP53 lead to a loss of this repression, resulting in sustained SLC7A11 activity and greater cellular resistance to ferroptosis (Leu et al., 2019)
Retatrutide is a triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors, currently in Phase 3 clinical trials
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