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if only B12 is deficient, hydroxocobalamin may allow longer intervals

Benefits of B12 Injections For people who are deficient, correcting B12 levels can produce noticeable improvements in: Energy levels and reduction in fatigue Mood stability and reduction in depressive symptoms Cognitive clarity and memory Nerve sensation and reduction in tingling or numbness Red blood cell production and resolution of anemia symptoms Balance and coordination (if nerve damage has not become irreversible) It is important to note: for people whose B12 levels are already normal, additional B12 does not provide extra energy or performance benefits

PMID: 9849822 The Discovery of Growth Hormone-Releasing Hormone: An Update Jett, L., Lger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D

The authors recommended screening for chromium deficiency in both prediabetics and diabetics, and supplementing if a deficiency was identified (Rafiei 2014)