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The ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), expressed on the luminal endothelial plasma membrane, are pivotal in CNS pharmaco-resistance [24, 30,31,32]

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These could include a combination of treatment for anywhere on the face, including the jowls, cheeks, jawline, chin, nose, marionettes, nasolabial folds, lips (and maybe some Bo'Tox a consultation prior to treatment would be required