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Even the small folate cycle can only proceed to a limited extent because the supply of THF from the large folate cycle is no longer given

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The procurement-optimal strategy for most high-volume LOE events: commit to a preferred supplier relationship with one or two of the anticipated early ANDA entrants in exchange for day-one supply at a meaningful discount to brand WAC (typically 25% to 40% below WAC at entry), with contractual price steps tied to market entrant milestones