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What Each Receptor Does GLP-1 (Glucagon-Like Peptide-1) Stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety through hypothalamic signaling

Lilly's dual GLP-1/GIP agonist reached Phase 3 in 2019 and read out body-weight reductions of roughly 22% at the 15 mg dose in SURMOUNT-1, meaningfully above semaglutide's ~15%

UCP-1 mRNA levels in 5- and 10-day-old JVS mice were significantly decreased compared with those in 5- and 10-day-old controls (Figure 4b)

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