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115 Recent studies highlight that metformin and aspirin have significant antiproliferative, cytotoxic, and antimigratory effects on PIK3CA-mutant HT-29 CRC cells, presenting a promising treatment option for this genetic subtype of CRC
38,39 In the MONICA/KORA study, the overall prevalence of neuropathic pain was 13.3% among diabetes patients, 8.7% in those with impaired glucose tolerance, 4.2% in those with impaired fasting glucose, and 1.2% in individuals with normal glucose tolerance
Nonetheless, its relevance to human biology needs to be addressed by more investigations
Liraglutide alleviates hepatic steatosis by activating the TFEB-Regulated autophagy-lysosomal pathway
Meta-analyses did not find differences compared with other drugs for T2DM, though a higher risk was noted with liraglutide ( Retrospective cohort study of obese or T2DM patients reported cases showing no linkor even improvementin suicidality, with reduced risk of sudden or recurrent suicidal thoughts (Wang et al., 2024)
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